Current Issue : January - March Volume : 2018 Issue Number : 1 Articles : 5 Articles
Ebsteinââ?¬â?¢s anomaly is a rare congenital heart disease that presents with apical displacement of the septal and posterior leaflets of the\ntricuspid valve. It has a wide spectrum of clinical presentations and has been shown to manifest itself any time from birth to\nadulthood. Our patient is a 43-year-old male with a history of intravenous heroin abuse who presented to the emergency department\nwith worsening shortness of breath and lower extremity edema. He denied any prior cardiac history. A transthoracic echo showed\nnormal left ventricular function, but a large 2.2 Ã?â?? 2.1 cm echodensity on the septal leaflet of the tricuspid valve consistent with\nvegetation with severe tricuspid regurgitation and probable leaflet perforation. It also demonstrated severe right heart enlargement\nwith atrialization of the right ventricle and apical displacement of the tricuspid valve consistent with Ebsteinââ?¬â?¢s anomaly. This is a rare\ncase of an adult who presented with asymptomatic Ebsteinââ?¬â?¢s anomaly. There have been few reports of tricuspid valve endocarditis\nwith Ebsteinââ?¬â?¢s anomaly in the literature. To our knowledge, this represents the fifth reported case of a new diagnosis of Ebsteinââ?¬â?¢s\nanomaly in the setting of endocarditis and the second case of Ebsteinââ?¬â?¢s anomaly and endocarditis in an intravenous drug abuser....
Background. Acute coronary syndrome (ACS) can complicate acute ischemic stroke, causing significant morbidity andmortality. To\ndate, literatures that describe poststroke acute coronary syndrome and itsmorbidity andmortality burden are lacking. Methods.This\nis a single center, retrospective study where clinical characteristics, cardiac evaluation, and management of patients with suspected\npoststroke ACS were compared and analyzed for their association with inpatient mortality and 1-year all-cause mortality. Results.\nOf the 82 patients, 32% had chest pain and 88% had ischemic ECG changes; mean peak troponin level was 18, and mean ejection\nfraction was 40%. The medical management group had older individuals (73 versus 67 years, ...
Background.The main objective of this meta-analysis was to investigate whether remote ischemic preconditioning (RIPC) reduces\ncardiac and renal events in patients undergoing elective cardiovascular interventions. Methods and Results. We systematically\nsearched articles published from 2006 to 2016 in PubMed, EMBASE, Web of Science, Cochrane Library, and Google Scholar.\nOdds ratios (ORs) with 95% confidence intervals (CIs) were used as the effect index for dichotomous variables. The standardized\nmean differences (SMDs) with 95% CIs were calculated as the pooled continuous effect. Sixteen RCTs of 2435 patients undergoing\nelective PCIwere selected.Compared with control group, RIPC could significantly reduce the incidence of perioperativemyocardial\ninfarction (OR = 0.64; 95% CI: 0.48ââ?¬â??0.86; ...
The present investigation evaluates the cardiovascular effects of the anorexigenic mediator\nalpha-melanocyte stimulating hormone (MSH), in a rat model of type 2 diabetes. Osmotic mini pumps\ndelivering MSH or vehicle, for 6 weeks, were surgically implanted in Zucker Diabetic Fatty (ZDF)\nrats. Serum parameters, blood pressure, and weight gain were monitored along with oral glucose\ntolerance (OGTT). Echocardiography was conducted and, following sacrifice, the effects of treatment\non ischemia/reperfusion cardiac injury were assessed using the isolated working heart method.\nNicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity was measured to evaluate\nlevels of oxidative stress, and force measurements were performed on isolated cardiomyocytes to\ndetermine calcium sensitivity, active tension and myofilament co-operation. Vascular status was also\nevaluated on isolated arterioles using a contractile force measurement setup. The echocardiographic\nparameters ejection fraction (EF), fractional shortening (FS), isovolumetric relaxation time (IVRT),\nmitral annular plane systolic excursion (MAPSE), and Tei-index were significantly better in the\nMSH-treated group compared to ZDF controls. Isolated working heart aortic and coronary flow was\nincreased in treated rats, and higher Hill coefficient indicated better myofilament co-operation in the\nMSH-treated group. We conclude that MSH improves global heart functions in ZDF rats, but these\neffects are not related to the vascular status....
The current study investigates the functional state of erythrocytes and indices of the oxygen-binding capacity of hemoglobin in\nblood samples from healthy donors and from patients with coronary artery disease and myocardial infarction before and after\ntreatment. It has been established that, in cardiovascular diseases, erythrocyte morphology and hemoglobin oxygen-transporting\ndisorders are observed. Standard therapy does not result in the restoration of the structure and properties of erythrocytes. The\nauthors believe that it is necessary for future therapeutic treatment to include preparations other than cardiovascular agents to\nenhance the capacity of hemoglobin to transport oxygen to the tissues.\n1. Introduction\nCurrently, cardiovascular diseases are the most common diseases\nand are one of the leading causes of death and disability\namong able-bodied populations in economically developed\ncountries [1ââ?¬â??3]. By 2020, the World Health Organization\nestimates that there will be nearly 25 million deaths due to\ncardiovascular diseases worldwide.\nMore than half of deaths due to cardiovascular system\ndiseases are caused by coronary artery disease (CAD). One\nin fivemen aged from50 to 59 years suffers fromthis disease,\nand the incidence and mortality rates are increasing every\nyear.Coronary artery disease may causemyocardial infarction,\napoplectic attack, or heart failure. Acute heart failure (AHF)\nremains one of the most actual and important problems of\nmodern cardiology. Acute heart failure is a clinical syndrome\ncharacterised by early onset of disturbed cardiac function\nsymptoms (reduced cardiac output and inadequate blood\nsupply)...
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